Skin Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Skin Cancer, including details on identification, causes, prevention, treatment.

Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice.

Zhang X, Kundoor V, Khalifa S, Zeman D, Fahmy H, Dwivedi C

Department of Pharmaceutical Sciences, 1 Administration Lane, College of Pharmacy, Box 2202C, South Dakota State University, Brookings, SD 57007, USA.

The objective of this study was to determine the chemopreventive effects of sarcophine-diol (SD) on 7,12-dimethylbenz(a)anthracene initiated and 12-O-tetradecanoylphorbol-13-acetate promoted skin tumor development in mice and its possible mechanisms of action. SD pretreatment significantly (P<0.05) decreased skin papilloma development during promotion phase. SD significantly (P<0.05) increased caspase-3 and decreased cyclooxygenase-2 during initiation phase or promotion phase. SD significantly (P<0.05) increased caspase-8 during promotion phase. SD resulted in a 95% reduction in 12-O-tetradecanoylphorbol-13-acetate-induced DNA synthesis. SD could be an effective chemopreventive agent for skin cancer by enhancing apoptosis and decreasing cell proliferation.

Published 11 June 2007 in Cancer Lett, 253(1): 53-9.
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