Skin Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Skin Cancer, including details on identification, causes, prevention, treatment.

Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder tumors.

Hernández S, Toll A, Baselga E, Ribé A, Azua-Romeo J, Pujol RM, Real FX

Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

Epidermal nevi (EN) are benign lesions presenting at birth or in childhood. Based on the occurrence of fibroblast growth factor receptor 3 (FGFR3) mutations in seborrheic keratosis and urothelial carcinomas (UC), and the identification of two young patients with EN and UC, we hypothesized that mutations might occur in EN. The R248C mutation was found in 6/23 (26.1%) EN but it was absent from unaffected skin. In two patients with EN and UC, both lesions were FGFR3 wild type. Our findings indicate that: (1) FGFR3 mutations occur in mosaicism and can cause EN and (2) other genes are involved in EN.

Published 14 June 2007 in J Invest Dermatol, 127(7): 1664-6.
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