Skin Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Skin Cancer, including details on identification, causes, prevention, treatment.

Primary cutaneous anaplastic large cell lymphoma associated with vascular endothelial growth factor arising from a burn scar.

Morihara K, Takenaka H, Morihara T, Kishimoto S

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. moriyan@koto.kpu-m.ac.jp

We present a case of primary cutaneous anaplastic large cell lymphoma manifesting with widespread erythema around an ulcer. Skin biopsy from the ulcer showed CD30-positive atypical lymphocytes throughout the dermis, and immunostaining demonstrated that these cells produced vascular endothelial growth factor, a potent stimulus for angiogenesis. Skin biopsy from the erythema revealed rich neovascularization, which was probably associated with vascular endothelial growth factor.

Published 16 October 2007 in J Am Acad Dermatol, 57(5): S103-5.
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