Skin Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Skin Cancer, including details on identification, causes, prevention, treatment.

A 30-year history of CD4+ vesiculo-bullous mycosis fungoides and multiple visceral malignancies.

Pearce A, Reid C, Gramp A, Sidhu S

Royal Adelaide Hospital, Department of Dermatology, Adelaide, SA, Australia. annette.pearce@ozemail.com.au

An 83-year-old Caucasian woman presented with a 25-year history of an itchy, eczematous blistering eruption affecting her trunk and acral sites. She had a past history of adenocarcinoma of the lung, colorectal carcinoma and bladder carcinoma. Several skin biopsies consistently showed features of a spongiotic process. Direct and indirect immunofluorescence studies were repeatedly negative, excluding the possibility of an autoimmune blistering disorder. A skin biopsy several years later, however, showed histological and immunophenotypic features of mycosis fungoides. The literature on this rare phenotype of cutaneous T-cell lymphoma generally portrays a negative prognosis. Our case illustrates an excellent prognosis with stable disease 30 years after onset.

Published 15 January 2007 in Australas J Dermatol, 48(1): 46-9.
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