Skin Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Skin Cancer, including details on identification, causes, prevention, treatment.

Sebaceous skin lesions as clues to hereditary non-polyposis colorectal cancer.

Lynch HT, Fusaro RM, Lynch PM

Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA. htlynch@creighton.edu

Cutaneous lesions consonant with Muir-Torre syndrome strongly suggest hereditary non-polyposis colorectal cancer (HNPCC). Ponti et al. discuss the importance of combining molecular genetic features of the sebaceous neoplasms, including microsatellite instability and immunohistochemistry, with family history, to determine the likelihood of HNPCC. Proof of diagnosis is identification of one of the mismatch repair germline mutations.

Published 19 September 2006 in J Invest Dermatol, 126(10): 2158-9.
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