Skin Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Skin Cancer, including details on identification, causes, prevention, treatment.

Cancer chemopreventive effects of Pinus Maritima bark extract on ultraviolet radiation and ultraviolet radiation-7,12,dimethylbenz(a)anthracene induced skin carcinogenesis of hairless mice.

Kyriazi M, Yova D, Rallis M, Lima A

School of Electrical and Computer Engineering, National Technical University of Athens, Iroon Politechniou 9, Zografou Campus, 157 80 Athens, Greece. chmaria@central.ntua.gr

The bark extract of Pinus Maritima (PBE), a rich in phenolic acids, polyphenols and in particular flavonoids mixture, was examined for skin cancer preventive action that was evaluated in two different experimental animal tumor models induced by ultraviolet radiation (UVR) and combination of UVR with 7,12-dimethylbenz[a]anthracene. Significant decrease in the number of animals bearing tumors and the number of tumors per animal was observed in the PBE treated animals. In the same time significant increase in the viability of these animals was also observed. Furthermore, PBE delayed the appearance of tumors. These results provide strong evidence about the preventive anticancer activity of this extract on non-melanoma skin cancer and its protective effect not only from UVR, but also from more potent carcinogenic agents.

Published 1 June 2006 in Cancer Lett, 237(2): 234-41.
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